Norflex Plus Orphenadrine 50 tabs


Norflex Plus Orphenadrine

Norflex Plus Orphenadrine is used for the temporary relief of acute skeletal or muscular pain that impairs patients' quality of life. Can be used not only as an independent agent but also in combination with non-steroidal anti-inflammatory drugs to achieve the best effect. It’s used as an anti-Parkinsonian drug to increase dopamine levels.

Release and composition forms

Norflex Plus Orphenadrine is a drug to relax the muscles and relieve spasms, available as tablets for oral administration. The package contains 50 tablets. Each tablet contains 35 mg of orphenadrine and 450 mg of paracetamol. 
Each component performs its own function. Orphenadrine eliminates painful sensations and returns comfort, and paracetamol enhances its action and slows the spread of the inflammatory process.

The maximum concentration of the active components is observed 2-4 hours after intake. The analgesic effect lasts up to 5-6 hours. The spent drug is excreted mainly by the kidneys with the urine.

Action in the body

Orphenadrine has a complex action. It works simultaneously as an anesthetic (similar to lidocaine), antihistamine (similar to diphenhydramine), and analgesic (similar to nefopam). What is the effect of the active substance on the body:

  • blocks histamine and muscarinic receptors;
  • inhibits sodium channels;
  • regulates the reuptake system of the hormone norepinephrine.

As a result, the conduction of nerve impulses is disrupted, which leads to the alleviation of skeletal and muscular pain. The pills help to relieve pathological tension without provoking atony. Healthy muscle fibers are not affected. Additionally, the substance has a sedative and anti-allergic effect.

Paracetamol as part of the drug has a moderate anti-inflammatory and analgesic effect. It’s a safe substance that can reduce body temperature, relieve pain, accelerate the healing of soft tissues.

Indications for prescribing Norflex Plus Orphenadrine

The tablets are recommended for use in such cases:

  • muscle spasms;
  • diseases of the musculoskeletal system, accompanied by acute or chronic pain;
  • parkinsonism.

Possible prescription Norflex Plus Orphenadrine short course during recovery from injury or surgery.

Contraindications to use

The tablets aren’t used in following cases:

  • intolerance to one or more components of the drug;
  • glaucoma;
  • progressive peptic ulcer disease;
  • blockage of the bladder;
  • severe cardiac disorders.

Use under 18 years of age is prohibited. Use as an analgesic in pregnancy in the 1st and 2nd trimesters is possible if the risk to the fetus is justified by the potential benefit to the mother. The active ingredients penetrate unimpeded into the breast milk. If the reception of Norflex Plus Orphenadrine during lactation is necessary, breastfeeding is stopped.

Possible side effects

Against the background of long-term treatment of tablets with orphenadrine in the composition may:

  • allergic rashes;
  • skin itching;
  • tachycardia;
  • rapid breathing;
  • pain in the stomach;
  • nausea;
  • intestinal disorders;
  • urinary retention;
  • general weakness;
  • tremors of the extremities;
  • nasal congestion;
  • blurred vision. 

Overdose of the drug

If the recommended dose is exceeded, the patient develops signs of intoxication - nausea, vomiting, diarrhea. Headaches, seizures aren’t excluded. In severe cases, respiratory depression, paralysis, and renal failure may occur. Treatment of overdose is symptomatic. There is no specific antidote. In mild intoxication, gastric lavage is indicated, in severe - forced diuresis.

Admission of the drug affects the CNS. The active ingredients may cause headaches, confusion, dizziness, somnolence. Against the background of admission, concentration decreases, anxiety and restlessness develop. During treatment, it is forbidden to perform work that requires quick reactions. It’s forbidden to drive vehicles.

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